 Until 2002, the route's southern terminus was at U.S. Route 22 (US 22), and the extension south of the US 22 interchange is known as the Gen. Anthony Clement McAuliffe 101st Airborne Memorial Highway.The route is commonly used as a hazmat bypass for the Pennsylvania Turnpike's Northeast Extension due to the restrictions in place on the Lehigh Tunnel.PA 33 provides a freeway connection between the Lehigh Valley and Pocono Mountains regions of Pennsylvania.