 Its real function is unclear, but it seems to play a role in the relation between the LDL receptor and clathrin-coated pits.People with autosomal recessive hypercholesterolemia tend to have more severe disease than "LDLR"-heterozygotes but less severe than "LDLR"-homozygotes.LDL cholesterol normally circulates in the body for 2.5 days, and subsequently the apolipoprotein B portion of LDL cholesterol binds to the LDL receptor on the liver cells, triggering its uptake and digestion.