 The route widens to a divided highway as it comes to an interchange with I-81 in a commercial area.Past this interchange, PA 16 leaves Greencastle for Antrim Township and becomes Buchanan Trail East, passing more businesses and briefly becoming a three-lane road with a center left-turn lane before becoming a two-lane undivided road again.The road runs through farmland with some homes, passing to the south of a large industrial complex and passing through the residential community of Shady Grove.