 The route continues east and enters the borough of Greencastle, where it becomes West Baltimore Street and passes a few homes before it comes to an intersection with US 11 in a business area.Past this intersection, PA 16 crosses under Norfolk Southern's Lurgan Branch and heads into the downtown area of Greencastle, coming to a traffic circle at Carlisle Street.From here, the road becomes East Baltimore Street and leaves the downtown, passing through residential areas.