 The section of the present route in McConnellsburg became part of the Lincoln Highway in 1913, PA 1 in 1924, and US 30 in 1926, with PA 1 removed from US 30 two years later.PA 16 was designated in 1928 to run along the Buchanan Trail between US 30 (Lincoln Way) in McConnellsburg and MD 32 (now MD 140) at the Maryland border southeast of Carroll Valley, replacing the previous PA 51 designation that had been assigned to the road a year earlier.A related route PA 851 is evidence of the route's former designation.