 KCNE1 is also reported to regulate two other KCNQ family α subunits, KCNQ4 and KCNQ5.KCNE1 increased both their peak currents in oocyte expression studies, and slowed the activation of the latter.,

KCNE1 also regulates hERG, which is the Kv α subunit that generates ventricular IKr.KCNE1 doubled hERG current when the two were expressed in mammalian cells, although the mechanism for this remains unknown.