 In the early 18th century, the Ohio Valley was settled by a multi-cultural group of Indians called the Mingo.They lacked a central government and, like all other Indians within the region at that time, were subject to the control of the Iroquois Confederacy (comprising the Seneca, Cayuga, Onondaga, Oneida, Mohawk, and Tuscarora people) headquartered in Upstate New York.The Mingo originally lived closer to the Atlantic Coast, but European settlement had pushed them into western Virginia and eastern Ohio.