 On 10 December 2005, Mitchell stopped Mohammed Medjadji in six rounds to win the vacant IBF Inter-Continental super-featherweight title, his first regional championship.Further success followed on 28 October 2006, when Mitchell defeated George Ashie by twelve-round unanimous decision to win the vacant Commonwealth super-featherweight title.Two defences of this title came against Harry Ramogoadi on 10 March 2007 (sixth-round TKO) and Carl Johanneson on 8 March 2008 (ninth-round TKO).