 On the residue-number criticism, Wrinch extended her model to allow for other numbers of residues.In particular, she produced a "minimal" closed cyclol of only 48 residues, and, on that (incorrect) basis, may have been the first to suggest that the insulin monomer had a molecular weight of roughly 6000 Da.Therefore, she maintained that the cyclol model of globular proteins was still potentially viable and even proposed the cyclol fabric as a component of the cytoskeleton.