 Firstly, the hypothesis assumes that two peptide groups can be crosslinked by a cyclol reaction (Figure 1); these crosslinks are "covalent" analogs of "non-covalent" hydrogen bonds between peptide groups.These reactions have been observed in the ergopeptides and other compounds.Secondly, it assumes that, under some conditions, amino acids will naturally make the maximum possible number of cyclol crosslinks, resulting in cyclol molecules (Figure 2) and cyclol fabrics (Figure 3).