 The route begins in Oxford and passes through rural areas of western Chester County, serving Cochranville, Parkesburg, Compass, and Honey Brook.The route passes through a small corner of Lancaster County before it enters Berks County and reaches Morgantown, where it has interchanges with Interstate 176 (I-176) and the Pennsylvania Turnpike (I-76).Between Morgantown and Reading, PA 10 parallels I-176.