 Greenhow and Snow both advocated for the usage of chloroform when performing major surgery.Greenhow's son, surgeon Henry Martineau Greenhow, reported in "The Lancet" his father's surgical success involving chloroform.Thomas Greenhow and his nephew, physician Edward Headlam Greenhow, undertook much research into medical hygiene and public health, publishing papers throughout the 1850s warning of further impending cholera pandemics.