 In her initial article, Wrinch stated clearly that the cyclol model was merely a "working hypothesis", a potentially valid model of proteins that would have to be checked.Her goals in this article and its successors were to propose a well-defined testable model, to work out the consequences of its assumptions and to make predictions that could be tested experimentally.In these goals, she succeeded; however, within a few years, experiments and further modeling showed that the cyclol hypothesis was untenable as a model for globular proteins.