 In this case, cell destruction occurs randomly, not orderly, and during a significantly longer (compared with apoptosis) time interval.UV-irradiated cells do not change their appearance for a long time [1, 6], as a result of which the researchers may make the erroneous conclusion that “revealed an unexpected response to a dose at which a higher dose of UV increased the viability of keratinocytes” [2].The fact that UV-induced apoptosis at high doses of UVR begins to be replaced by necrosis was established in 2000 [3].