 The main active component marrubiin has both antioxidant and cardioprotective properties and has shown to significantly improve myocardial function.One experimental animal study suggests that the aqueous leaf extract of "Leonotis leonurus" possesses antinociceptive, antiinflammatory, and hypoglycemic properties.An animal study in rats indicated that in high doses, lion's tail has significant toxicological adverse effects on organs, red blood cells, white blood cells and other important bodily functions.