 From 1880 to 1884 he was a member of bacteriologist Robert Koch's staff in Berlin, and later worked at Carl Remigius Fresenius' institute (the "Chemischen Institut Fresenius)" in Wiesbaden.From 1889 to 1912 he was a professor at Charles University in Prague.Hueppe is remembered for his pioneer investigations of hormesis in regards to chemical stimulation/inhibition of bacterial growth.