 The cell then undergoes rounding, shrinkage and blabbing before condensation of chromatin is observed in the nucleus.After a period of time the cell fragments into apoptotic bodies, which in vivo are engulfed and degraded by phagocytic cells such as macrophages"  Caspase I is involved in the aforementioned cell membrane activity but not caspase-3.The sequence of events that leads to apoptosis is multifaceted and complex.