 In 1912, the Bank of Brandywine was chartered from what had previously been the Southern Maryland German-American Bank.Although located between the substantial bedroom cities of Clinton and Waldorf, Brandywine remained rural until after the turn of the twenty-first century, when shopping centers - including big-box stores, and small residential developments were built.By mid-2019, relief should come from daily commuter traffic bottlenecks, when completion of a major highway overpass, and a roundabout, will eliminate two traffic signals.