 F-spondin is a secreted protein that also binds ApoER2 and leads to phosphorylation of Dab1.Alzheimer's disease is the most common form of dementia, and studies have shown that manipulation of pathways involving LRP8/ApoER2 can lead to the disease.Certain alleles, such as apoe, app, ps1 and ps2, may lead to being genetically predisposed to the disease.