 Decreased expression of ApoER2 is associated with certain neurological diseases.ApoER2 is a protein made up of 870 amino acids.It is separated into a ligand binding domain of eight ligand binding regions, an EGF-like domain containing three cysteine-rich repeats, an O-linked glycosylation domain of 89 amino acids, a transmembrane domain of 24 amino acids, and a cytoplasmic domain of 115 amino acids, including an NPXY motif.