 ApoE competes with reelin in binding to ApoER2 resulting in weakened reelin signaling.Reduced reelin signaling leads to impaired plasticity in neurons and increases in the phosphorylation of tau protein, which is a microtubule stabilizing protein that is abundant in the Central Nervous System (CNS), producing neurofibrillary tangles which are implicated in Alzheimer's disease.Antiphospholipid syndrome is an autoimmune disease characterized by thrombosis and complications during pregnancy, often leading to fetal death.