 This occurs through Dab-1 activation of Src family kinases, which have been shown to play a role in regulating synaptic plasticity.VLDLR also acts as a receptor coupled to ApoER2 as it does during development, but its role is not well understood.ApoER2 plays a more important role in this process, most likely due to its ability to bind the PSD-95 adapter protein through the 59 amino acid insert on its cytoplasmic tail.