 This interaction with the two receptors activates intracellular processes that begin with the phosphorylation of Dab1, a tyrosine kinase phosphorylated protein which is encoded by the DAB1 gene.This protein associates with the NPXY motifs on the intracellular tails of ApoER2 and VLDLR.Upon reelin binding, Dab1 is phosphorylated by two tyrosine kinases, Fyn and Src.