 ApoER2 is thought to play a key role in the process of platelet binding.β2GPI has the proper binding site for interaction with ApoER2 and other LDL family receptors, and it is speculated that the antibody/β2GPI complexes interact with ApoER2 on platelets.This causes the phosphorylation of a p38MAPkinase, resulting in the production of thromboxane A2.