 Histidine biosynthesis is carefully regulated by feedback inhibition/

R5P can be converted to adenosine diphosphate ribose, which binds and activates the TRPM2 ion channel.The reaction is catalyzed by ribose-5-phosphate adenylyltransferase

Diseases have been linked to R5P imbalances in cells.Cancers and tumors show upregulated production of R5P correlated to increased RNA and DNA synthesis.