 Superactivity in PRPS1, the enzyme that catalyzes the R5P to PRPP, has also been linked to gout, as well as neurodevelopmental impairment and sensorineural deafness.Ogden Reservoir (Greater Manchester)

Ogden Reservoir is a reservoir in the Piethorne Valley, close to Milnrow and Newhey in the Metropolitan Borough of Rochdale, within Greater Manchester, England.The reservoir was commissioned in 1878 collecting water from Piethorne Brook and Wickenhall Brook, to provide drinking water for Oldham.