 The group designed new ligands for complexation of iron and aluminium, technology that was used to treat patients suffering from iron or aluminum overload.He cowrote a book on his pioneering research in the chemistry of metal chelate compounds with Nobel Laureate Melvin Calvin, and wrote or edited fourteen other textbooks that are in use by hundreds of chemists and biologists, including works on "Critical Stability Constants" (six volumes, with R.M.Smith), "The Determination and Use of Stability Constants" (with R.J. Motekaitis) and "Metal COmplexes in Aqueous Solutions" (with R.D.