 The deletion in 3 base pairs in the "TALDO1" gene results in the absence of serine at position 171 of the transaldolase protein, which is part of a highly conserved region, suggesting that the mutation causes the transaldolase deficiency that is found in erythrocytes and lymphoblasts.The deletion of this amino acid can lead to liver cirrhosis and hepatosplenomegaly (enlarged spleen and liver) during early infancy.Transaldolase is also a target of autoimmunity in patients with multiple sclerosis.