 Minor allele of SNP rs630923, located in the area of CXCR5 gene promoter and associated with the risk of multiple sclerosis, is responsible for appearance of MEF2C-binding site resulted in reduced CXCR5 gene promoter activity in B-cells during activation, that could lead to decreased autoimmune response 

While chemokines and chemokine receptors have been thought to be involved in cancer development and maintenance, recently CXCR5 has come under investigation for its role in metastatic progression of prostate cancer.A recent study has indicated that prostate cancer tissue as well as cell lines express higher non-basal levels of CXCR5.Furthermore, the study found a correlation between the level of CXCR5 and Gleason score.