 Karmsaddeh have been home for a very ancient settlement as one can still find ruins going most probably to the Greek and Roman (and maybe Phoenician) periods in the vicinity of the village, especially in the area of the extinct village of Qarheen ().According to some Historians, Qarheen was destroyed by the Mamluks at the end of the 13th Century and its inhabitants took refuge in Karmsaddeh.It is arguably known that Karmsaddeh has been inhabited for up to 2,000 years.