 The 22nd Massachusetts was present for virtually all of the major battles in which the Army of the Potomac fought, including the Second Battle of Bull Run, the Battle of Antietam, the Battle of Fredericksburg, the Battle of Chancellorsville, the Battle of Gettysburg and Lieutenant General Ulysses Grant's Overland Campaign.The 22nd was especially proficient in skirmish drill and was frequently deployed in that capacity throughout the war.During the Siege of Petersburg in October 1864, the 22nd Massachusetts was removed from the lines and sent home to Massachusetts.