 Adenylosuccinate synthase

In molecular biology, Adenylosuccinate synthase (or adenylosuccinate synthetase) () is an enzyme that plays an important role in purine biosynthesis, by catalysing the guanosine triphosphate (GTP)-dependent conversion of inosine monophosphate (IMP) and aspartic acid to guanosine diphosphate (GDP), phosphate and N(6)-(1,2-dicarboxyethyl)-AMP.Adenylosuccinate synthetase has been characterised from various sources ranging from "Escherichia coli" (gene purA) to vertebrate tissues.