 In vitro studies of "ETV6-RUNX, ETV6-MN1, ETV6-PER1", and "ETV6-MECOM" fusion genes support this notion.Thus, the "ETV6-MECOM" fusion gene is overexpressed because it is driven by the promoter derived from "ETV6" whereas the "ETV6-RUNX, ETV6-MN1", and " ETV6-PER1" fusion genes produce chimeric proteins which lack ETV6 protein's gene-suppressing activity.The chimeric protein products of "ETV6" gene fusions with "ARNT, TTL, BA22A, FCHO2, MDS2", and "CHIC2" likewise lack ETV6 protein's transcription factor activity.