 In conjunction with U.S. Route 65 in Iowa (US 65), Iowa 14 and US 20, Iowa 330 is commonly used as a connector between Des Moines and the Waterloo–Cedar Falls area.Iowa 330 begins at an interchange with Interstate 80 (I-80), U.S. Route 6 (US 6), and US 65 in Altoona.The I-80 freeway runs east–west; US 6 comes up from the southwest along Hubbell Avenue and joins eastbound I-80 while US 65 exits eastbound I-80 and turns onto Hubbell heading northeast.