 Thus the study not only characterized Jak3 interaction with Shc, but also demonstrated the mechanism of intracellular regulation of Jak3 activation where Jak3 interactions with Shc acted as a regulator of Jak3 dephosphorylation through direct interactions of Shc with both Jak3 and tyrosine phosphatases.Chronic low-grade inflammation (CLGI) plays a key role in metabolic deterioration in the obese population.Jak3 expression and activation provide protection against development of CLGI and associated health complications.