 The acute lymphoblastic leukemia associated with L349P or N385fs mutations in "ETV6" appeared far less sensitive to standard chemotherapy for acute lymphoblastic leukemia with 2 among 3 family members moving rather quickly from chemotherapy to bone marrow transplantation and the third family member expiring.This suggest that these mutation-related forms of acute lymphoblastic leukemia require aggressive therapy.The "ETV6" gene is prone to develop a wide range of acquired mutations in hematological precursor cells that lead to various types of leukemia and/or lymphoma.