 In 1923, the portion of present US 322 along the US 40 concurrency was designated as a part of pre-1927 Route 18S, a route that was built to connect Penns Grove to Atlantic City.As a result of the creation of the U.S. Highway System in 1926, U.S. Route 40 was also signed along the alignment Route 18S.A year later, in the 1927 New Jersey state highway renumbering, the current alignment of US 322 through New Jersey was designated as a part of Route 42 between Williamstown and McKee City, while Route 48 replaced the Route 18S designation along the portion between McKee City and Atlantic City.