 It has been implicated in IFN-α, IL-6, IL-10 and IL-12 signaling.This gene encodes a member of the tyrosine kinase and, to be more specific, the Janus kinases (JAKs) protein families.This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits.