 In September 1862, Wisner was stricken with typhoid fever while en route to the regiment's deployment and died in Kentucky.The 22nd Michigan Infantry was mustered out of service on June 26, 1865.The regiment suffered 3 officers and 86 enlisted men who were killed in action or mortally wounded and 4 officers and 306 enlisted men who died of disease, for a total of 399 
fatalities.