 Iowa 330 begins at an interchange with Interstate 80 (I-80), U.S. Route 6 (US 6), and US 65 in Altoona.The I-80 freeway runs east–west; US 6 comes up from the southwest along Hubbell Avenue and joins eastbound I-80 while US 65 exits eastbound I-80 and turns onto Hubbell heading northeast.For the first of its routing, Iowa 330 shares the same roadway with US 65.