 US 322 intersects several major roads including U.S. Route 130 and Interstate 295 in Logan Township, the New Jersey Turnpike in Woolwich Township, Route 55 in Harrison Township, Route 42 in Williamstown, Route 50 and U.S. Route 40 in Hamilton Township, the Garden State Parkway in Egg Harbor Township, and U.S. Route 9 in Pleasantville.East of Williamstown, US 322 follows the Black Horse Pike, a turnpike between Camden and Atlantic City that was created in 1855.Pre-1927 Route 18S was designated along the portion of the current route east of McKee City in 1923, with the US 40 designation along this portion following in 1926.