 MD 529 was redesignated along an old alignment of US 13 that had previously been MD 663 from Fruitland to Salisbury in the mid-1960s before being removed around 1981.MD 529 begins at an acute intersection with MD 675 (Somerset Avenue) just north of Princess Anne.The state highway curves to the east and crosses the Delmarva Central Railroad's Delmarva Subdivision rail line.