 At least 9 frameshift mutations in the"'ETV6" gene have been associated with ~12% of adult T cell Acute lymphoblastic leukemia cases.These mutations involve insertions or deletions in the gene that lead to its encoding a truncated and therefore inactive ETV6 protein.These mutations commonly occur alongside mutations in another oncogene, "NOTCH1", which is associated with T cell acute lymphoblastic lymphoma quite independently of ETV6.