 5,6-MDO-DMT was first synthesized by Alexander Shulgin.In his book "TiHKAL" ("Tryptamines I Have Known and Loved"), 5,6-MDO-DMT produces no noticeable psychoactive effects, although it was only tested up to a dose of 5mg.Very little data exists about the pharmacological properties, metabolism, and toxicity of 5,6-MDO-DMT.