 From 1966 until his retirement in 1991, Wyman taught in the History Department at the University of Massachusetts Amherst, where he twice chaired the Judaic studies program.Wyman held honorary doctoral degrees from Hebrew Union College and Yeshiva University, both in New York City.He was chairman of the David S. Wyman Institute for Holocaust Studies in Washington, D.C.

Deborah Lipstadt characterizes Wyman's book, "Paper Walls