 The name of Opodepe comes from the Opata language, from the roots "opo", which means iron wood, "det" flat, and "pa" place, "in the plain of the ironwood".In 1704, Father Kino founded the mission settlement of Nuestra Señora de la Asunción de Opodepe in this town.The land is divided between hills and flatland and the main settlement lies at an elevation of 596 meters.