 This study highlights that as pests gain resistance to traditional chemical insecticides, the use of transplastomics to deliver RNAI- mediated crop protection strategies could become increasingly viable in the future.Another notable transplastomics based approach is the production of artemisinic acid through transplastomic tabaco plants which is the precursor molecule that can be used to produce artemisinin.Artemisinin- based combination therapy is the preferred and recommended treatment of choice by the WHO (World Health Organization) against malaria.