 His close relationship with King Louis led in 1820 to the creation of what became the "Académie Nationale de Médecine", of which he was lifelong president.In 1803 he published "Cours d'anatomie médicale", a 5-volume work on medical history.He was probably the first to describe amyloid in liver in 1789 when he noted a lard-like substance in an elderly woman's liver.