 Nagalase catalyzes the deglycosylation of the Gc protein also known as vitamin D3 binding protein (VDBP) rendering it incapable of being converted to the regulatory protein, Gc Macrophage Activating Factor (GcMAF).GcMAF is an immunologically important protein responsible for macrophage activation, thus Nagalase diminishes the body’s macrophage activating capacity, and elevated Nagalase has been reported in autoimmune disorders including systemic lupus erythematosus (SLE).Elevated Nagalase levels have also been found in the blood of children with autism and autism spectrum disorders(ASDs).