 Along with Antonio Berni, Spilimbergo and Mexican muralist David Alfaro Siqueiros, he created a series of murals for a villa belonging to local businessman Natalio Botana, in Don Torcuato.Castagnino traveled to Paris in 1939, where he attended the atelier of cubist painter André Lhote, later traveling across Europe perfecting his art and in the company of Georges Braque, Fernand Léger and Pablo Picasso, among others.Castagnino returned to Argentina in 1941, where he enrolled at the University of Buenos Aires and obtained a degree in architecture.