 Reversing and preventing gingival enlargement caused by drugs is as easy as ceasing drug therapy or substituting to another drug.However, this is not always an option; in such a situation, alternative drug therapy may be employed, if possible, to avoid this deleterious side effect.In the case of immunosuppression, tacrolimus is an available alternative which results in much less severe gingival overgrowth than cyclosporin, but is similarly as nephrotoxic.