 Arredondo earned his first career victory on May 26, 2008, against the Detroit Tigers in Anaheim, throwing two perfect innings of relief in an Angels' 1–0 12-inning victory.On June 28, he pitched in relief of Jered Weaver and combined with Weaver to not allow a hit against the Los Angeles Dodgers, but still lost the game 1–0.This was only the fourth time an eight-inning no-hitter had ever been lost due to the home team winning the game, and the first as a combined no-hitter.