 Bypass US 66 in Springfield, Missouri was a short lived bypass created when Interstate 44 was built on the north side of the city and the main route was concurrent with I-44.It was located on Kearney Street and West Bypass and, as the city expanded across it, was redesignated Business US 66 when that route was moved from downtown.Much (but not all of the highway) is currently Route 744.

Business US Highway 66 (also "City US 66" until 1960) was an old alignment of U.S. Route 66 in Springfield, Missouri.