 Gravois Road is Route 30, and Chippewa Street and Watson Road are now Route 366.

Business US 66 in the East St. Louis, Illinois area followed the older main alignment of U.S. Highway 66 through St. Louis metropolitan area when US 66 was routed around the north and west sides of St. Louis.It followed Nameoki Road, Edwardsville Road, and 10th Street, eventually crossing the MacArthur Bridge to join (a different) Business US 66 in St. Louis.The route was created in 1938, and the designation was removed in 1969.