 The Lyre River flows roughly northwest out of Lake Crescent, first encountering June Creek, then turning north at the point that is joined by Boundary Creek on the left.At River Mile 2.7 () the river tumbles down the Lyre River Falls, which are impassable to fish migrating upstream.Continuing north, the river is joined by Susie Creek on the left, and finally Nelson Creek on the right before emptying into the Strait of Juan de Fuca at Low Point.