 For nearly fifty years he practised in Southwark, and from 1856 to 1859 he was Medical Officer of Health for the parish of St. George the Martyr, Southwark.He lived at Treverbyn, Forest Hill, and died there on 18 Sept. 1893, leaving issue four sons and one daughter.Rendle was deeply interested in the borough of Southwark, and engaged in laborious researches into its history.