 In 1904, Hume moved south again, accepting work as a professor of botany and horticulture at the Florida Agricultural College in Lake City, Florida, one of the University of Florida's four predecessor institutions, and thereafter held the same position at the modern University of Florida in Gainesville, Florida.During his time as a professor, Hume also served as the horticulturalist and botanist with the university-affiliated Florida Agricultural Experiment Station.He was a published author and recognized expert on the cultivation of citrus fruits and pecans.