 The road would eventually become the main route of US 66, with the older alignment becoming Business US 66.

Business US 66 in Joplin, Missouri was a business route of U.S. Route 66 and was the former alignment of the main road.It was created when the main route was moved to the bypass route of the highway.The road followed the now historic alignment of the highway (Zora Street, Florida Avenue, Utica Street, Euclid Street, St. Louis Avenue, Broadway, and Main Avenue), all of which (except Main) are now city streets.