 For instance, "N. magadii" is an aerobic chemoorganotrophic, dual extremophile requiring alkaline conditions and hypersalinity for optimal growth.Those harsh conditions resulted in changed composition of charged amino acids in the proteins (average isoelectric point is only 4.64, whereas other organisms average is 6.5) with almost all proteins being highly acidic.The genome of "N. magadii" consists of four replicons with a total sequence of 4,443,643 bp and encodes 4,212 putative proteins.