 He lost in the first round of the Australian Open to Alexandr Dolgopolov, 1–6, 6–4, 4–6, 2–6.At the 2016 Memphis Open, Berankis defeated Dudi Sela, Damir Džumhur, and Donald Young to reach the semi-finals, losing to an in-form Taylor Fritz in three sets, despite being up a set.Berankis reached two consecutive challenger finals in Raanana and Gwangju, losing the former to Evgeny Donskoy and winning the latter without dropping a set, defeating Grega Zemlja and adding a sixth ATP challenger title.