 Set primarily in Italy during German-occupied Europe in World War II, the film tells the story of four Buffalo Soldiers of the 92nd Infantry Division who seek refuge in a small Tuscan village, where they form a bond with the residents.The story is presented as a flashback, as one survivor, Hector Negron (Alonso), reflects upon his experiences in a frame story set in 1980s New York.Several real-life events that occurred during the war, such as the Sant'Anna di Stazzema massacre, are re-enacted, placing "Miracle at St. Anna" within the genre of historical fiction.