 He was accepted as a missionary by the American Board and at the close of 1822 sailed for Malta and thence the next year went to Beirut, where he aided in establishing the station which became the center of the Syrian mission.In 1828, on account of threatened war between England and Turkey, the missionaries removed to Malta, where Goodell labored in preparing and printing books for the mission; until, in 1831, the way having been opened by the destruction of the Turkish fleet at Navarino, he went to Constantinople, where he commenced the Armeno-Turkish mission.During his missionary life he and his devoted wife cheerfully endured many trials and perils and were compelled to move their residence 33 times in 29 years.