 Chronic CX-614 treatments produce rapid increases in the synthesis of the brain-derived neurotrophic factor BDNF which has very important effects on synaptic plasticity  and may have applications in the treatment of neurodegenerative diseases such as Alzheimer's disease.Acute CX-614 treatments activate local mRNA translation (new protein synthesis) within dendrites  and this is mediated by a fast upregulation of BDNF release.CX-614-dependent release of BDNF rapidly increases translation of proteins that are important for synaptic plasticity such as ARC/Arg3.1 and CaMKIIalpha.