 "L. noguchii" also uses the Lsa24 protein to avoid the immune system of the host and antibacterials by binding to factor H. While the most important virulence factor has not yet been identified, some of the other proteins that are considered to be contributors to the main virulence are hemolysins, more specifically phospholipase C, sphingomylinase-like proteins, and pore-forming proteins.The disease typically begins with fever, and will then lead to other symptoms.The symptoms in humans include