 Yoshihara et al.reported 60% of pediatric asthmatic patients demonstrating acute symptoms were found to have creola bodies in their sputum.These patients had increased levels of neutrophil-mediated cytokine activity concluding that "epithelial damage is associated with a locally enhanced chemotactic signal for and activity of neutrophils, but not eosinophils, during acute exacerbations of paediatric asthma."