 P53 can upregulate GBP2 and play an essential role in the tumor development by inhibition of metalloproteinase MM9 as well as NF-Kappa B and Rac protein.The transcriptional level of GBP2 is also regulated by two transcription factor STAT1 and IRF1.GBP2 expression have a strong correlation with T cell metagene which seems an association with the infiltration of T cell in the breast cancer.