 Salcedo's most famous role came in 1961, when he starred as the titular character in Gerry de Leon's "The Moises Padilla Story", a film biography of a Negros Occidental mayoral candidate who in 1951, was tortured and murdered by the private army of the provincial governor after he had refused to withdraw his candidacy.For this role, Salcedo won his first FAMAS Best Actor award.He would win another FAMAS, this time as Best Supporting Actor, in 1976 for his portrayal of a zarzuela actor in Eddie Romero's "Ganito Kami Noon, Paano Kayo Ngayon".