 In addition, the Isoprenylation is required to regulate the intracellular localization and the membrane association of GBP2.The murine GBP2 gene is not just highly activated by the interferon-gamma during macrophages activation but also by the stimulation of Toll-like receptors, Tumor necrosis factor (TNF) and Interleukin 1 beta.After the stimulation of interferon gamma, GPB2 murine is expressed in the innate and adaptive immune cells.