 The territory that is now Colorado County has been continually inhabited by humans for about 12,000 years.The Coco branch of the Karaknawa are said to have hunted in the area, while Tonkawa crossed the area from the south.The first record of an Anglo settler coming through the area that is now Colorado County was January 20, 1687, when René Robert Cavelier, Sieur de La Salle camped along Skull Creek.