 Cherokee County comprises the Jacksonville, TX Micropolitan Statistical Area, which is also included in the Tyler-Jacksonville, TX Combined Statistical Area.The Hasinai group of the Caddo tribe built a village in the area in around AD 800
 and continued to live in the area until the 1830s, when they migrated to the Brazos River.The federal government moved them to the Brazos Indian Reservation in 1855 and later to Oklahoma.