 Another family subunit IL-17RE is highly expressed in Th17 cells.Signaling via IL-17R protects our body against several bacterial and fungal infections caused by invading pathogens, especially against "Candida albicans".Binding of proinflammatory cytokin IL-17A to IL-17 receptor causes important conformational changes that enable binding of signaling adaptors, such as Act1 or TRAF proteins.