 Adult-AMKL can result from the progression of other myeloproliferative neoplasms (MPN) viz., chronic myelogenous leukemia, polycythemia vera, essential thrombocytosis, and primary myelofibrosis.In one review of adult-AMKL, 25% of 49 cases were considered as secondary to one of these MPN.The mechanism behind these cases of secondary AMKL are unknown although an inversion in chromosome 3 at positions q21 and q26, i.e.