 The genes suffering these mutations include "TP53, FLT3, ERG, DYRK1A, CHAF1B, HLCS, RUNX1, MIR125B2" (which is the gene for microRNA MiR125B2CTCF, "STAG2, RAD21, SMC3, SMC1A, NIPBL, SUZ12, PRC2, JAK1, JAK2, JAK3, MPL, KRAS, NRAS", and "SH2B3".At least one but probably several of these mutations, whether occurring in individuals with silent or symptomatic TMD, are presumed responsible for or to contribute to the development of DS-AMKL.Rare cases of transient myeloproliferative disease and DS-AMKL occur in individuals who do not have Down syndrome.