 He is perhaps most known for his work with Vincent T. DeVita in which he developed the combination chemotherapy CMF, which was one of the first combination therapies for breast cancer.The two also collaborated to create the MOPP regimen for Hodgkin's lymphoma.As former chair of the Lymphoma Committee of the Cancer and Leukemia Group B (CALGB), a national American cooperative trials group, Canellos initiated many practice-changing clinical trials of cancer therapies.