 Opoku spent some time at Dutch club Excelsior and Belgian club Royal Antwerp FC before returning to the Ghana.Opoku signed with Feyenoord Ghana for one year and joined in 2006 Asante Kotoko and in the 2007–2008 season Opoku won the Ghana Premier League title and the Ghana President's Cup with Asante Kotoko.The attacking midfielder and forward on 31 January 2010 left his club Asante Kotoko and signed a four-month loan deal with Dinamo Tirana.