 From 1971 to 2011, he served as the founding scientific and medical director of the Cancer Research Institute (CRI), where from 2001 to 2011 he also served as director of the CRI/LICR Cancer Vaccine Collaborative (CVC), an international network dedicated to testing and optimizing therapeutic cancer vaccines.Old’s previous appointments included Chairman of the LICR Board of Directors (2006–2009), LICR Scientific Director (1988 to 2005), Member of the Emeritus LICR Scientific Committee (1971–86), LICR Chief Executive Officer (1995–2004), and Associate Director of Research at MSKCC (1973–83).Old served as a member of scientific advisory boards and committees including the Public Health Research Institute of the City of New York, the National Cancer Institute, and the American Association for Cancer Research.