 Ergotamine is the main psychoactive product of ergot fungi; it is structurally related to the drug lysergic acid diethylamide (LSD-25) and is the substance from which LSD-25 was originally synthesized.The same fungus has also been implicated in other major historical anomalies, including the Salem witch trials.However, John Waller in "The Lancet" argues that "this theory does not seem tenable, since it is unlikely that those poisoned by ergot could have danced for days at a time.