 On 18 December he opened his goal scoring for Benfica, scoring twice in a 5–2 home win against Rio Ave.

After a relatively slow start to Portuguese football, Salvio became a regular fixture for Benfica in the second part of the campaign, partnering several compatriots in the squad and usually appearing as a right winger.On 20 February 2011 he scored the first goal in a 2–0 away win against city rivals Sporting and, three days later, he netted his first goal in European competition, with an impressive 20-yard strike against Stuttgart in the Europa League's round of 32 (2–0 away success, 4–1 on aggregate); to finalize that week, in a home league match against Marítimo, he scored the equalizer minutes after the away side opened the scoring, in an eventual 2–1 home win, and finished the campaign with 39 official games and ten successful strikes.Salvio officially returned to Atlético on 19 May to begin his rehabilitation on a calf injury sustained whilst still at Benfica, in a Europa League game against PSV.