 In 38 BC Laodice and Orodes with their children, were in a parricidal and fratricidal massacre perpetrated by Phraates IV of Parthia to whom Orodes II handed over the Parthian throne after the death of Orodes’ son Pacorus I of Parthia in battle in 38 BC.When Laodice died, her brother King Mithridates II of Commagene had her body returned to Commagene.She was buried near her mother Isias, her sister Antiochis of Commagene and her niece Aka I of Commagene.