 What is important to consider is that there are also three lysine clusters in the N-terminal domain (NTD), which are important for the interaction with eIF2B.Moreover, the sequence of the protein comprises a zinc finger motif that was shown to play a role in both ternary complex and 43S preinitiation complex formation.There are also two guanine nucleotide-binding sequences that have not been shown to be involved in the regulation of eIF2 activity.