 For example, increased concentrations of active PKR and inactive (phosphorylated) eIF2 were found in patients suffering from neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and Huntington’s disease.There is also one proven example of a disease related to the GEF eIF2B.Mutations in all of the five subunits of eIF2B could be linked with leukoencephalopathy, an illness that causes the brain’s white matter to disappear.