 He was drafted by the Baltimore Orioles on June 8, 1965, in the third round of the 1965 amateur draft.He was then drafted from the Orioles by the New York Yankees on November 28, 1966 in the 1966 first-year draft.Tepedino made his major league debut on May 12, 1967 with the Yankees in a game against Orioles at Yankee Stadium, with 22,300 in attendance.