 After narrowly escaping the plague which ravaged Piedmont in 1630, he was appointed ambassador to the French court, and had audience of Louis XIII in May 1631.Isaac Wake was spoken of as likely to succeed Viscount Dorchester as secretary of state when the latter died in February 1632; but before the appointment was made he died himself, from an attack of fever, at Paris in June 1632.His body was brought to England with the ceremony due to his rank, and buried in the chapel of Dover Castle.