 This study demonstrated the CuAAC mediated conjugation of formula_1 with two different fluorophores and the antibiotic levofloxacin, showcasing the potential of covalently functionalized recombinant spider silk proteins as biomaterials with enhanced properties.The researchers were able to successfully conjugate formula_1 with alkyne fluorophores, proving the protein can be functionalized through an azide group while conjugated to the axis of the silk fiber.Their results showed not only an intense uniform fluorescence along the fiber axis but also an intense uniform composite fluorescence when the fiber was decorated with two different fluorophores in a 1