 On the contrary, CISNE should not be used so much to select low-risk patients for outpatient treatment.Generally, patients with febrile neutropenia are treated with empirical antibiotics until the neutrophil count has recovered (absolute neutrophil counts greater than 500/mm3) and the fever has abated; if the neutrophil count does not improve, treatment may need to continue for two weeks or occasionally more.In cases of recurrent or persistent fever, an antifungal agent should be added.