 It is classically marked by weight gain due to fluid retention, increased liver size, and raised levels of bilirubin in the blood.The name sinusoidal obstruction syndrome is preferred if VODI happens as a result of chemotherapy or bone marrow transplantation.Apart from chemotherapy, VODI may also occur after ingestion of certain plant alkaloids such as pyrrolizidine alkaloids (in some herbal teas), and has been described as part of a rare hereditary disease called "hepatic venoocclusive disease with immunodeficiency" (which results from mutations in the gene coding for a protein called SP110).