 However, if either the player or a splicer gets too close to a Little Sister, the Big Daddy will assume an aggressive stance in attempt to scare off the transgressor.If either the Big Daddy or the Little Sister is attacked (intentionally or accidentally), the Big Daddy will retaliate against the attacker until it or the attacker is dead.A 'Hypnotize Big Daddy' plasmid can be obtained to hypnotize Big Daddies into protecting the player, but the Little Sister will be abandoned, so the player loses the chance to obtain ADAM.