 This system could be used in combination with computational modeling to rapidly assess responses to new drug candidates, providing critical information on their safety, efficacy, and pharmacokinetics.Other new technologies from Ingber's lab include development of a fully biodegradable plastic alternative inspired by natural cuticle material found in shrimp shells and insect exoskeletons, known as “Shrilk”; a mechanically activated nanotherapeutic that selectively directs clot-busting drugs to sites of vascular occlusion while minimizing unintended bleeding; an siRNA nanoparticle therapy that prevents breast cancer progression; a dialysis-like sepsis device that cleanses blood of all infectious pathogens, fungi and toxins without requiring prior identification; a surface coating for medical materials and devices that prevents clot formation and bacteria accumulation that reduces the need for use of conventional anticoagulant drugs that frequently result in life-threatening side effects, and a computational approach to diagnostics and therapeutics that incorporates both animation and molecular modeling software to virtually develop and test potential drugs designed to fit precisely into their targets’ molecular structures.Earlier in his career, Ingber helped to bridge Harvard University, its affiliated hospitals, and the Massachusetts Institute of Technology (MIT) through his involvement in the Center for Integration in Medicine and Innovative Technology, Harvard-MIT Division of Health Sciences and Technology, and Dana-Farber/Harvard Cancer Center.