 The fold of the prepuce maintains sub-preputial wetness, which mixes with exfoliated skin to form smegma.The American Academy of Pediatricians' 2012 technical report on circumcision found that the foreskin tends to harbor micro-organisms that can lead to urinary tract infections in infants and tend to contribute to the transmission of sexually transmitted infections in adults.The foreskin is specialized tissue that is packed with nerves and stretch receptors.