 Following his 3rd place qualifying effort and leading 5 laps on his way to a 5th place finish at Fontana, Karam captured his season best finish at the 2015 Iowa Corn 300 at Iowa Speedway in July, by finishing 3rd.In his Pennsylvania homecoming at Pocono Raceway for the 2015 ABC Supply 500 on August 23, Karam was leading with 21 laps remaining when he lost control exiting turn 1, eliminating his Chip Ganassi number 8 Dallara as it spun and crashed hard into the wall.Debris strewn from Karam's disintegrating car made contact with fellow competitor Justin Wilson's helmet, sending him into the infield wall where the safety team extracted him unconscious and unresponsive, necessitating an emergency medevac to Lehigh Valley Hospital in Allentown where Wilson lay comatose, in critical condition.