 On a one race agreement for 2016, Dreyer & Reinbold signed Karam for the Indianapolis 500, initially with Havoline and Gas Monkey Garage as sponsors.Steadily improving from his 23rd qualifying slot on grid, into the top 10, Karam crashed on lap 94, going Townsend Bell into Turn One.On a successive one race agreement, again Dreyer & Reinbold signed Karam to drive the Mecum Auctions #24 Dallara-Chevrolet for the 2017 Indianapolis 500.