 Activity of stavudine was shown to be similar to that of zidovudine, although their phosphorylation patterns differ; the
affinity for zidovudine to thymidine kinase (the enzyme responsible for the first phosphorylation) is similar to that of thymidine, whereas the affinity for stavudine is 700-fold weaker.2',3'-dideoxy-3'-thiacytidine (lamivudine, 3TC) was discovered by Bernard Belleau.The history

of lamivudine can be traced back to the mid-1970s while Bernard Belleau was investigating sugar derivatives.