 He also taught experimental oncology at the University of Paris (1966 to 1990), created and managed (from 1980 to 1988) the Service des Maladies Sanguines et Tumorales in the Hôpital Paul-Brousse where he blended research and therapy with groundbreaking methods and results in chemotherapy and immunotherapy to develop polytherapies adapted to individual cases..He played a crucial role in the development of several important molecules such as acriflavine, bestatine, ellipticine, oxaliplatine, triptoreline and vinorelbine and actively participated in the development of polychemotherapy and chrono-chemotherapy.