 The N-acetyl binding and binding pocket, binding of the ring system and important domains are somewhat known and need further investigation.Carbamate insecticides target human melatonin receptors.There are three melatonin agonists on the market today (February 2014); ramelteon (Rozerem), agomelatine (Valdoxan, Melitor, Thymanax) and tasimelteon (Hetlioz).