 It led to slight regressions or stable disease in patients with papillary renal carcinoma and poorly differentiated gastric cancer.AMG 458 is a potent small molecule c-MET inhbitor which proved to have more than a 100-fold selectivity for c-MET across a panel of 55 kinases.Also, AMG 458 was 100% bioavailable across species and the intrinsic half-life increased with higher mammals.