 On 23 February 2016, Dybala scored his first UEFA Champions League goal in a 2–2 home draw to Bayern Munich in Juventus' first round of 16 leg.On 15 March, it was announced Dybala would miss the second round of 16 leg of the Champions League against Bayern on 16 March due to an edema overload of his left soleus muscle.He returned to action four days later in a 4–1 away win over Torino, but was substituted after sustaining yet another injury.