 One-atom linker was more efficient than a two-atom linker and that substitution at the benzylic position seemed to be tolerated.Compounds with heterocyclic hinge binding elements (quinoline, pyridine, azaindole) linked to fused, nitrogen-dense heteroaromatics (triazolopyridazines, triazolopyrazines and triazolotriazines) have been described.See figure 4 for details.