 Later, great varieties of malabaricanes were discovered in other organisms, mostly in marine sponges such as "Rhabdastrella globostellata".Isomalabaricanes are malabaricanes in which the three carbon rings of the molecule are connected in "trans−syn−trans" conformation, as opposed to other malabaricanes, where the rings are connected in "trans−anti−trans" conformation.They are of particular research interest because many of them have been reported to show anti-tumour activity in cell culture.