 Wijewardene's father was Don Edmund Wijewardene (brother of D. R. Wijewardena) and his mother was Corin Amanda Jennings, both of whom were gynaecologists.In 1949 Wijewardene married Seela, the daughter of Benjamin de Mel (a brother of Sir Henry De Mel) and Marjorie Perera Abeywardene (a granddaughter of Sir Charles Henry de Soysa).Anoma, Roshni and Mandy are their daughters.