 Kingsport is the largest city in the Kingsport–Bristol–Bristol, TN-VA Metropolitan Statistical Area (MSA), which had a population of 309,544 as of 2010.The Metropolitan Statistical Area is a component of the Johnson City–Kingsport–Bristol, TN-VA Combined Statistical Area – commonly known as the "Tri-Cities" region.Census data from 2006–2008 for the Tri-Cities Combined Statistical Area estimates a population of 496,454.