 Murrysville is a control city on the sign for eastbound US 22 at the eastern end of I-376 in Monroeville.According to the United States Census Bureau, the Municipality had a total area of , of which, of it is land and 0.03% is water.Among the neighborhoods within Murrysville are Murrysville Heights, Heather Highlands, Franklin Estates, Settlers Ridge (The Ridge), Dunningtown, Newlonsburg, Ringertown, Sardis, and White Valley.