 In 2017, this Organization classified PBL as the most common member of a rare subgroup of lymphomas termed lymphoid neoplasms with plasmablastic differentiation.In addition to the immunodeficiency-causing viral disease, HIV/AIDS (which is an AIDS-defining clinical condition), recent studies have diagnosed PBL in individuals who have one or more other causes for immunodeficiency.These causes include prior organ transplantation; immunosuppressive drugs; autoimmune and chronic inflammatory diseases (e.g.