 While the affinity is the highest for the Kv2.1 and Kv4.2 channels, it has been shown that the toxin may also bind to α1A voltage-gated Ca2+ channels ().Hanatoxin binds to the S3-S4 link of K+ channel-subunits, specifically the S3b segment (, ), and may bind to multiple subunits in a single ion channel .Similar to α-scorpion toxins, Hanatoxin inhibits – but does not block – the activation of, primarily, voltage-gated potassium channels.