 On March 13, 2019, Nsekhe signed a two-year, $14.5 million deal including $7.7 million in guarantees with the Buffalo Bills.On September 23, 2013, Nsekhe was the subject of a controversy after he responded to a tweet originally written by Morgan Reed and retweeted by actor and model Daniel Bostic whom Nsekhe follows.The tweet read, "Hard to believe that a player in a helmet defendin' a football makes more money than a soldier in a helmet defendin' his country."