 HNTX-III and HNTX-IV cause spontaneous contractions of the diaphragm muscle and the vas deferens smooth muscle of the rat.HNTX-III and HNTX-IV are able to paralyze cockroaches, and HNTX-IV can even paralyze rats.Intracerebroventricular injection in mice with HNTX-II shows a LD50 of 1.41 μg/g.