 GxTX-1 shows sequence similarities with Jingzhaotoxin-III (JZTX-III), "Grammostola spatulata" mechanotoxin-4 (GsMTx-4), and Voltage-sensor toxin-1 (VSTX1) peptides.GxTX-1 consists of two variants, GxTX-1D and GxTX-1E, of which GxTX-1E is a more potent inhibitor of Kv2.1.GxTX-1D and GxTX-1E consist of 36 amino acids, differing only a single amino acid at the NH2-terminal, aspartate or glutamate, respectively