 Since the passage of the Combat Methamphetamine Epidemic Act of 2005, the Drug Enforcement Administration has reported a sharp decline in domestic meth lab seizures, but drug cartels continue to meet demand by manufacturing meth in Mexico and smuggling it across the border.In 2012, the DEA seized a total of of methamphetamine and shut down 11,210 meth labs., the Sinaloa Cartel is the most active drug cartel involved in smuggling illicit drugs like methamphetamine into the United States and trafficking them throughout the United States.