 Invasion of GBM into NHA in 3D culture provides a powerful new assay for basic cancer biology and drug screening (right, 12h to 252h).By facilitating assembly of different populations of cells using the MLM, consistent generation of organoids termed adipospheres capable of simulating the complex intercellular interactions of endogenous white adipose tissue (WAT) can be achieved.Co-culturing 3T3-L1 pre-adipocytes in 3D with murine endothelial bEND.3 cells creates a vascular-like network assembly with concomitant lipogenesis in perivascular cells.