 For an artificial material to bond to living bone, the formation of bonelike apatite layer on the surface of an implant is of significant importance.The SBF can be used as an in vitro testing method to study the formation of apatite layer on the surface of implants so as to predict their in vivo bone bioactivity.The consumption of calcium and phosphate ions, present in the SBF solution, results in the spontaneous growth of bone-like apatite nuclei on the surface of biomaterials in vitro.