 Selected to play his second All-Star Futures Game for 2016 at Petco Park in San Diego, Reyes was the starting pitcher for the World team, striking out four of the five outs he recorded as World won, 11−3.His 2016 totals with Memphis included a 2−3 record, 4.96 ERA, 93 strikeouts and 32 walks in 65 innings.The Cardinals purchased Reyes' contract on August 9, 2016, and added him to the major league roster to serve as a relief pitcher.