 The series revolves around the Mixels, small creatures that can mix and combine with one another in creative and unpredictable storylines.Although previous Lego series, such as "" and "Legends of Chima" use CGI animation, "Mixels" made use of Toon Boom Harmony software, which is animated at Atomic Cartoons, Inc., before later being animated traditionally at Digital eMation, Inc., Big Star Entertainment, Inc., and Saerom Animation, Inc..

A mobile app was released for the series on March 4, 2014, named "Calling All Mixels", and even earlier two websites, one on the LEGO website and another owned by Cartoon Network, were launched where fans can learn about the Mixels.Nine series of collectible Lego building toys were released, based on the characters.