 SC 781 is a two-lane rural connector highway between US 278 and US 78.Established in 1940 as a new primary route, it traversed from SC 28 in Beech Island east to US 78 west of Williston.In 1953, SC 781 was truncated to its current western terminus, replaced by a rerouted SC 28 (later became US 278 in 1965).