 This strategy offers a facile means for preparation of pyridnyl aryl systems that are important fragments of many useful drug scaffolds.In 1992, Robinson and co-workers developed a similar pyridine synthesis using enamino nitriles as one of the three-carbon fragments in place of an α-pyridinium methyl ketone.This improvement increases the reactivity of the system and allows for formation of fully substituted pyridines whereas use of an α-pyridinium methyl ketone requires that the 3- or 5- position on the resulting pyridine be unsubstituted.