 On January 10, 2017, Randle signed a 10-day contract with the Philadelphia 76ers.Four days later, he made his NBA debut in a 109–93 loss to the Washington Wizards, recording three points and one steal in six minutes off the bench.In his second game for the 76ers on January 16, he scored 10 points in a 113–104 win over the Milwaukee Bucks.