 He developed the paradigm of Lewis base activation of Lewis acids and successfully applied it to the asymmetric addition of a broad range of nucleophiles to sily ketene acetals, iodo- and bromo-functionalization of alkenes, and enantioselective thio- and seleno-functionalization of alkenes.His work has yielded several Lewis base catalysts that are chiral phosphoramide derivatives.Unlike other organocatalysts, the Lewis base catalysts operate without the assistance of H-bonding, therefore avoiding drawbacks and have a broad substrate scope.