 For example, the Chichibabin synthesis requires 2 equivalents of unsaturated starting material.Additionally, the byproducts of the Kröhnke synthesis is water and pyridine, which allow for easy workup and purification protocols.Unlike comparable methods for pyridine synthesis, the Kröhkne synthesis benefits from being a high-yielding one pot synthesis, which ultimately allows for abbreviation of synthetic pathways and further simplifies combinatorial library cataloging.