 Various methyl ketones 29 and aldehydes 30 were coupled via aldol condensation to give enones of the form 31.These compounds were then reacted with various α-pyridinium methyl ketones 32 to give the desired tri-substituted pyridine 33.In 2009, Tu and coworkers developed a 3 fragment, one-pot combinatorial strategy for developing 3-cyanoterpyridines 34and 1-amino-2-acylterpyridines 35.