 When using naloxone, the naloxone will be quickly eliminated and the withdrawal will be short lived.Doses of naltrexone take longer to be eliminated from the person's system.A common problem in treating methadone overdoses is that, given the short action of naloxone (versus the extremely longer-acting methadone), a dosage of naloxone given to a methadone-overdosed person will initially work to bring the person out of overdose, but once the naloxone wears off, if no further naloxone is administered, the person can go right back into overdose (based upon time and dosage of the methadone ingested).