 Individuals who are prescribed methadone for either IV or IM administration cannot drive in the UK, mainly due to the increased sedation effects that this route of use can cause.In the United States, deaths linked to methadone more than quadrupled in the five-year period between 1999 and 2004.According to the U.S. National Center for Health Statistics, as well as a 2006 series in the "Charleston Gazette" (West Virginia), medical examiners listed methadone as contributing to 3,849 deaths in 2004.