 Fibonacci (c. 1170 – c. 1250), and Gerolamo Cardano (1501–1576) made fundamental advances in mathematics.Luca Pacioli established accounting to the world.Physicist Enrico Fermi (1901–1954), a Nobel prize laureate, led the team in Chicago that developed the first nuclear reactor and is also noted for his many other contributions to physics, including the co-development of the quantum theory and was one of the key figures in the creation of the nuclear weapon.