 During World War I, the unit fought in numerous battles and campaigns including the Battle of Saint-Mihiel, Meuse-Argonne Offensive, and the Battle of Champagne, at Lorraine.After the First World War, the unit was reorganized and re-designated on 29 January 1921 as the 5th Medical Regiment.The 5th Medical Regiment was inactivated in August 1921 at Camp Jackson, South Carolina.