 Belisle led the team with a 1.76 ERA over 46 innings out of the bullpen, but he was left off the Nationals' roster for the 2016 National League Division Series against the Los Angeles Dodgers.On February 3, 2017, Belisle signed a one-year contract with the Minnesota Twins.Belisle began the season as the setup man for the Twins but after August, he was put as closer for the team for the remainder of the season.