 Belisle rejoined the Twins after signing a Major League contract with the team on June 11, 2018.In his second stint with the Twins, Belisle did not have a good outing, finishing the season with a 9.13 ERA in 25 appearances.On the final day of the season, Joe Mauer requested Belisle to be the pitcher on the mound when he appeared for one final pitch as a catcher before retiring after the game.