 The use of HCA is contraindicated in patients suffering Colitis or Inflammatory Bowel Disease.One isomer of HCA, known as (2"S",3"R")-HCA, inhibits pancreatic alpha-amylase and intestinal alpha-glucosidase, leading to a reduction in carbohydrate metabolism "in vitro".In a study in Zucker rats, which are genetically predisposed to obesity, "Garcinia cambogia" extract containing HCA showed that high doses led to significant suppression of epididymal fat accumulation, but also had high testicular toxicity.