 Just as the 2nd Colorado prepared to return for Indian-fighting duty in Colorado, Confederate General Sterling Price began his campaign to secure Missouri for the Confederacy.The 2nd Colorado was attached to the Union force raised to repel General Price's Missouri State Guards, and took part in the battles of the Little Blue River, Westport, Marais des Cygnes, and Mine Creek in October 1864.When Price withdrew, the 2nd Colorado was part of the pursuit, meeting him for the last time near Fayetteville, Arkansas, in November 1864.