 In 1520 Ludovico Borromeo built the castle "Rocca Vitaliana" at Castelli di Cannero, a fortification against the Old Swiss Confederacy.Giberto II Borromeo († 1558), Milanese governor at the Lago Maggiore, married Margherita Medici di Marignano, the sister of pope Pius IV and of condottiero Gian Giacomo Medici, Duke of Marignano.One of their sons, Carlo Borromeo (1538−1584), became a cardinal of the Roman Catholic Church, archbishop of Milan, and a canonized saint.