 In particular, expression of FOXC2 is induced when epithelial cells undergo an epithelial-mesenchymal transition (EMT) and become mesenchymal looking cells.EMT can be induced by a number of genes including Snail, Twist, Goosecoid, and TGF-beta 1.Overexpression of FOXC2 has been noted in subtypes of breast cancer which are highly metastatic.