 Absence of FOXC2 has been shown to lead to the failure of lymphatic valves to form and problems with lymphatic remodelling.A number of mutations in the FOXC2 gene have been associated with Lymphedema–distichiasis syndrome, It has also been suggested that there may be a link between polymorphisms in FOXC2 and varicose veins.FOXC2 is also involved in cancer metastases.