 Mayo High School was built in 1966 in the southeastern section of Rochester, Minnesota.It has a capacity to hold approximately 1800 students (Although historically the student populations of both Mayo and John Marshall high schools have exceeded well over 2,000 students) and was the largest high school in the city until Century High School was built, and was named after the brothers William James Mayo and Charles Horace Mayo, physicians and founders of Mayo Clinic.As of 2020, there are 1689 students attending Mayo High School.