 Serodiscordancy contributes to the spread of HIV/AIDS, particularly in Sub-Saharan nations such as Lesotho.Serodiscordant couples face numerous issues not faced by seroconcordant couples, including decisions as to what level of sexual activity is comfortable for them, knowing that practicing safer sex reduces but does not eliminate the risk of transmission to the HIV-negative partner.There are also potential psychological issues arising out of taking care of a sick partner, and survivor guilt.