 It was first identified in 1986 by Murry "et al".This group exposed anesthetised open-chest dogs to four periods of 5 minute coronary artery occlusions followed by a 5-minute period of reperfusion before the onset of a 40-minute sustained occlusion of the coronary artery.The control animals had no such period of “ischaemic preconditioning” and had much larger infarct sizes compared with the dogs that did.