 In the 2011-12 season, Pepe formed a formidable centre back partnership with Sergio Ramos.That campaign, he went on to make 29 appearances in La Liga and 45 appearances in all competitions as Real Madrid claimed their 32nd league title.On 19 August 2012, in the Liga opener against Valencia, Pepe collided with Real Madrid goalkeeper Iker Casillas in the play that led to the visitors equalizing the score 1–1 (the final result).