 The Queen blamed herself for this and as a result became thin, suffering bouts of depression.Between 1579 and 1586, both she and her husband made numerous pious offerings and pilgrimages, especially to Chartres and spa treatments in the hope of having an heir.As a result, the heir presumptive was (after the death of the King's brother Francis, Duke of Anjou in 1584) the controversial Henry III of Navarre, a fact which placed additional pressure upon both Louise and her husband.