 However, caution needs to be exercised, especially in the cases of contact granuloma resulting from external factors (i.e., when factors are eliminated, the contact granuloma resolves independently), because any irritation can cause the contact granulomas to reappear.As the masses of granular tissue are most often benign, prognosis is generally positive.However, due to the variety of treatment options and lifestyle factors, outcomes of individual treatments and form of management vary.