 The region is named for the Applegate River, which flows through the town of Applegate and near the city of Jacksonville.The Applegate Valley has been a grape-growing region since 1870 when A. H. Carson began planting 30 acres of grapes along North Applegate Road.One of Oregon's first wineries (the winery has been restored and re-opened as Valley View Winery) was established in the Applegate Valley.