 One study in 2016 led by Prof. Julia Simner showed subtle differences in the white matter structure in the brains of people with OLP, compared with control subjects.These harmless differences were in five clusters, in the pre-postcentral gyrus/ dorsal corticospinal tract, left superior corona radiata, and the genu, body and left side of the corpus callosum.A number of these regions play a role in social responsiveness (Simner et al., 2016)

The Pythagoreans, an ancient Greek cult of natural philosophers notable for their interest in numerology, personified the natural numbers by assigning gender to them; the odd numbers were male and the even female .