 Like his elder brother, he lived among the Iroquois during a period when the rivalry of the French and English to secure the alliance of that nation endangered the lives of the missionaries.His brother having returned to France due to poor health, in 1701, the sixty year old Lamberville returned to the mission among the Onondaga at their request, only to leave in 1709 through the intrigues of Abraham Schuyler, who instigated drunken Indians to burn the chapel and the priest's residence while Lamberville was away on a trip to Montreal.He then went to Cayuga, but in 1709 when war broke out, he went to Montreal, where he took on the management of the Hôtel-Dieu de Montréal.