 The motif takes its name from traditional nomenclature used in describing the protein parvalbumin, which contains three such motifs and is probably involved in muscle relaxation via its calcium-binding activity.The EF-hand consists of two alpha helices linked by a short loop region (usually about 12 amino acids) that usually binds calcium ions.EF-hands also appear in each structural domain of the signaling protein calmodulin and in the muscle protein troponin-C.



Additional points