 The most splendid occupant of the office of Chancellor was the future Pope Leo X, who received as residence from his successor Pope Clement VII the "Palazzo Riario", long known as the ""Cancellaria Apostolica"", where he remained.His former residence was in the "Palazzo Borgia", from which he moved to the "Palazzo Sforza Cesarini", the latter palace being, on this account, long known as the ""Cancellaria Vecchia"".The removal of the residence and office of the Vice Chancellor to the majestic "Palazzo Riario" in the "Campo di Fiori" was due to the confiscation of the property of Cardinal Raffaele Riario for his share, with Cardinals Petrucci, Sacchi, Soderini, and Castellesi, in a conspiracy against the life of Pope Leo X.

Contiguous to the "Cancellaria" "qua" edifice, in fact forming part of it, is the "Basilica di San Lorenzo in Damaso".