 The road from Abingdon northwest to Dickensonville (now part of U.S. Route 58 Alternate) was part of the original state highway system designated in 1918, as a spur of State Route 10 (now U.S. Route 11).It was assigned the number State Route 106 in the 1923 renumbering, and it was extended south and southwest five miles (8 km) towards the Tennessee state line in 1925.In the 1928 renumbering, the whole of SR 106 became State Route 110, and extensions added 3.12 miles (5.02 km) in 1929 and another 3.24 miles (5.21 km) in 1931.