 In 1501, Ottaviano dei Petrucci published the "Harmonice Musices Odhecaton", the first substantial collection of printed polyphonic music, and in 1516, Andrea Antico published the "Frottole intablate da sonari organi", the earliest printed Italian music for keyboard.Italy became the primary center of harpsichord construction, violin production started in Cremona in the workshop of Andrea Amati, and lutenist Francesco Canova da Milano earned Italy an international reputation for virtuosic musicianship.Music achieved new heights of cultural respectability.