 It consists of a diprolyl component and is highly conserved among N6-adenine methyltransferases as the DPPY motif, however, this motif can vary for N4-adenine and C5-cytosine methyltransferases.The DPPY motif has been found to be essential for AdoMet binding.Motifs IV-VIII play a role in the catalytic activity, while motifs 1-III and X play a role in binding of the cofactor.