 In his nineteen-year career as a football defender, which lasted from 1924 to 1943, he played for Casale, Bologna, and Roma.With Bologna, he was victorious in the 1928–29 championship, also winning two Mitropa Cups in 1932 and 1934.At international level, Monzeglio played for the Italian national team on 35 occasions, with which he also won two FIFA World Cup finals, in 1934 and 1938, being named to the Team of the Tournament in 1934; he also won two Central European International Cups with Italy.