 The program signed on on July 31, 2006 on flagship station WKTU, launching into syndication two weeks later.Wake Up with Whoopi aired from 5am - 9am local time (live on the East Coast) in several markets.At its peak, the program was heard on four of the top six major markets (New York's WKTU, Chicago's WLIT, San Francisco's KKSF and Philadelphia's WISX) and approximately twenty affiliates overall.