 Serrano worked as a lecturer at several schools, namely in Coegio Rafael Borja, Colegio Benigno Malo, Garaicoa Colegio, Colegio Rosa de Jesús Cordero, Colegio Fray Vicente Solano (served as president), then served as dean of the Faculty of Philosophy and Literature at the University of Cuenca and also taught at the Faculty of Law, University del Azuay in society.Serrano served as a board member of Canton Cuenca and later as a member of the House of Representatives at the provincial level in the province of Azuay.Later he was elected governor of the Azuay Province and then twice served as provincial deputy in the National Parliament.