 Physician Franz Masoch and his assistant Peter Krausnecker made significant contributions to the development of vaccination and the fight against Smallpox.Wojciech Bogusławski opened the first public theatre in 1794 and Józef Maksymilian Ossoliński founded in 1817 the Ossolineum, a scientific institute.Early in the 19th century the city became the new seat of the primate of the Ukrainian Greek Catholic Church, the "Archbishop of Kyiv (Kiev), Halych and Rus, the Metropolitan of Lviv".