 The limitations of the assay depend upon the methodology of the test.HPLC (High Performance Liquid Chromatography) can detect certain genetic variants and potential liver diseases affecting CDT.Used with other tests, such as gamma glutamyl transferase (GGT), aspartate aminotransferase (AST), and alanine aminotransferase (ALT), carbohydrate-deficient transferrin can be a useful tool in identifying problem drinking, such as alcohol abuse or alcoholism.