 He worked to identify specific oxidative mechanisms in atherosclerosis.He researched the effects of lipid peroxidation, oxidative stress, and modified lipoproteins in the progression of cardiovascular disease, seeking ways to convert research findings into therapeutic interventions.Along with his colleagues in the USC Atherosclerosis Research Unit, Sevanian identified a modified low-density lipoprotein (LDL) that contributes to atherosclerosis in humans.