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Twywell was the birthplace of the bluestocking writer Hester Chapone, née Mulso (1727–1801), whose conduct book "Letters on the Improvement of the Mind" (1773), addressed to a 15-year-old niece, remained influential and regularly reprinted for over fifty years.Horace Waller (1833–1896), anti-slavery activist, missionary and cleric, was Rector of the Anglican parish of Twywell from 1874 to 1895.The village is centred along the High Street and The Green.