 Trilostane was the first drug approved to treat both pituitary- and adrenal-dependent Cushing's in dogs.Only one other drug, Anipryl (veterinary brand name) selegiline, is FDA-approved to treat Cushing's disease in dogs, but only to treat uncomplicated, pituitary-dependent Cushing's.The only previous treatment for the disease was the use of mitotane (brand name Lysodren) off-label.