 This makes its appearance in three portions.The actual mechanism of septation of the outflow tract is poorly understood, but is recognized as a dynamic process with contributions from contractile, hemodynamic, and extracellular matrix interactions.Misalignment of the septum can cause the congenital heart conditions tetralogy of Fallot, persistent truncus arteriosus, dextro-Transposition of the great arteries, tricuspid atresia, and anomalous pulmonary venous connection.