 Deshmukh died on 27 February 2010 in the premises of Chitrakoot Gramoday Vishwavidyalaya that he established.He was unwell for some time due to geriatric problems and had refused to be taken to Delhi for treatment.He bequeathed his body to Dadhichi Dehdaan Sanstha of New Delhi which was accepted, and his body was sent to All India Institute of Medical Sciences for medical research.