 In 1975, Georges J. F. Köhler and César Milstein generated the first monoclonal antibodies using their own hybridoma technology.They started the field of monoclonal antibody development and won the Nobel Prize for Medicine in 1984 for their work.Soon after, muromonab-CD3 became the first fully licensed monoclonal antibody in 1986 for its use in treating kidney transplant rejection.