 Before the Byrd Expressway, West Virginia's segment of U.S. 22 ran from Pennsylvania Avenue at the PA/WV state line to Main St., then left on Main St. through downtown Weirton (aligning U.S. 22 with West Virginia Route 2), and right on Freedom Way to the Fort Steuben Bridge and Ohio River to Steubenville, Ohio.An "Alternate U.S. 22" route ran along Cove Road from Pennsylvania Avenue to the intersection of Harmon Creek Road (left turn) and the continuation of Cove Road.With the opening of the first segment of the Byrd Expressway in the mid-1970s, U.S. 22 was reassigned, starting on the new road from the PA/WV state line, continuing on Cove Road where the expressway ended and joining the remainder of the original route at Main St.