 Officially, US 22 Eastbound begins on Central Avenue (US 27 northbound/US 52 westbound/US 127 northbound) at 5th Street, then proceeds north, turning east onto 7th Street.Meanwhile, US 22 Westbound follows 9th Street and officially ends at Central Avenue (signage designating the end occurs much sooner, approaching Elm Street, U.S. Route 42 Northbound).From downtown Cincinnati to Washington Court House, US 22 roughly follows the historic 3C Highway which connected Cincinnati, Columbus, and Cleveland.