 In addition to cancer of the head, mouth, neck, throat, oesophagus, other aerodigestive tract cancers, and dental disease areca nut, the main ingredient in gutka is known to cause severe oral mucosal disorders.Oral submucous fibrosis, one such disorder, is a malignant condition that is severely debilitating and has no cure.Metabolic syndrome, hypertension, diabetes and obesity have also been linked to its use.