 In southwest Ohio, it overlaps with State Route 3 and is familiarly known as the 3C Highway, "22 and 3", and Montgomery Road.A section of US 22 in Pennsylvania between New Alexandria at U.S. Route 119 and Harrisburg at Interstate 81 has been designated a part of Corridor M of the Appalachian Development Highway System.US 22 has its westernmost end-point in downtown Cincinnati—however, its eastbound and westbound end-points are not at the same intersection.