 During the Mixtón War, settlers were attacked by the Caxcan, Portecuex, and Zacateco peoples under the command of Tenamaxtli.The war was initiated in response to the cruel treatment of indigenous peoples by Nuño de Guzmán, in particular the enslavement of captured natives.After multiple defeats, Viceroy Antonio de Mendoza took control of the Spanish campaign to suppress the revolt.