 Known as the Robert C. Byrd Expressway, the expressway route that began roughly 30 miles to the west near Cadiz, Ohio continues for approximately five miles within the state of West Virginia (the highway runs concurrent with WV 2 for one of those miles) as it approaches more population density within the Pittsburgh metro area.US 22 travels through or borders the city of Weirton for its entire length in West Virginia, from the Ohio state line over the Ohio River, to the Pennsylvania state line.US 22 enters Pennsylvania as a limited-access highway connecting Weirton, West Virginia, and Steubenville, Ohio, with Pittsburgh.