 Inhibition of estradiol can lead to serious developmental problems for both males and females, including sexual, skeletal, and mental development issues.In a cross-sectional study, PCBs were found to be negatively associated with testosterone levels in adolescent boys.High PCB levels in adults have been shown to result in reduced levels of the thyroid hormone triiodothyronine, which affects almost every physiological process in the body, including growth and development, metabolism, body temperature, and heart rate.