 He first married Gina Karel and they had one daughter, Rocío Guadalupe Prío-Socarrás-Karell.He then married María Dolores "Mary" Tarrero-Serrano (October 5, 1924 – September 23, 2010) on 17 June 1945 in the Chapel of the Presidential Palace, and they had two daughters, María Antonetta Prío-Tarrero (b.14 June 1946 in Cuba and married to César Odio, former City Manager of the City of Miami) and María Elena Prío-Tarrero (b.