 From Lancaster to Zanesville, US 22 roughly follows the route of Zane's Trace, an early pioneer road blazed by Colonel Ebenezer Zane beginning in 1796.Starting just west of Cadiz, US 22 becomes a limited-access expressway for the remainder of its 30-some miles in Ohio as it approaches and enters the Pittsburgh metropolitan area (with the exception of an at grade intersection with no stop lights or signs on US 22 and narrowing to two lanes for about a mile east of Cadiz).It junctions with State Route 7 for roughly a mile along the Ohio River shoreline in Steubenville.