 Studies in 2008 and 2010 indicate that both CSNB and leopard complex spotting patterns are linked to TRPM1.In 2007 the ApHC implemented new drug rules allowing Appaloosas to show with the drugs furosemide, known by the trade name of Lasix, and acetazolamide.Furosemide is used to prevent horses who bleed from the nose when subjected to strenuous work from having bleeding episodes when in competition, and is widely used in horse racing.