 It had a population of 756 in 1860 and 880 in 1870.The Anaheim district was enumerated separately from Santa Ana in 1870

Claimed in 1869 by Kentuckian William H. Spurgeon on land obtained from the descendants of Jose Antonio Yorba, Santa Ana was incorporated as a city in 1886 with a population of 2000 and in 1889 became the seat of the newly formed Orange County.In 1877, the Southern Pacific Railroad built a branch line from Los Angeles to Santa Ana, which offered free right of way, land for a depot, and $10,000 in cash to the railroad in exchange for terminating the line in Santa Ana and not neighboring Tustin.