 Matelica lies in an ample valley where the Braccano creek joins the Esino river, dominated by the town from an eastern ravine.The valley, roughly in the north–south direction, is delimited on the east and west sides by Apennines sub-ranges, whose highest peaks are respectively Mount Gemmo at and Mount San Vicino at , compared to the above sea-level of the city centre.Matelica borders on the following municipalities