 In addition to the truncation of the original protein, the iron-deficient "sla" phenotype may also be explained by the intracellular mislocalization of hephaestin.Wild type hephaestin localizes in a supra nuclear compartment as well as the basolateral surface.In contrast, "sla" hephaestin seems to localize only in the supranucelar compartment but is largely undetectable in the latter.