 When interpreting the zinc finger repertoires presented by investigations using ZFP phage display, it is important to appreciate the effects that the rest of the zinc finger framework may have had in these selections.Since the problem only appears to occur in a limited number of cases, the issue is nullified in most situations in which there are a variety of suitable targets to choose from and only becomes a real issue if binding to a specific DNA sequence is required (e.g.blocking binding by endogenous DNA-binding proteins).