 He worked as a physician in Bet She'an, where he died in 1355.Ishtori Haparchi was the author of the first Hebrew book on the geography of the Land of Israel, "Sefer Kaftor va-Ferach" (), literally "Book of Bulb and Flower", or "Knob and Flower," written in 1322 in the Land of Israel and published in Venice in 1549.