 On March 4, 2010, it was announced that Duno would return to the IRL IndyCar Series driving for Dale Coyne Racing full–time for the 2010 season.Duno failed to qualify for the 2010 Indianapolis 500.Duno competed in 16 of 17 races on the 2010 schedule and the "DNQ" at Indianapolis was the first and only race that she did not qualify for in her 43 race IndyCar Series career.