 His father was a judge for the Supreme Court of Hong Kong, and his brother was Percival Kinnear Wise.He married Cassandra Coke and had one son, Group Captain Adam Nugent Wise LVO MBE RAF, born 1943.He was elected to the House of Commons at the 1931 general election as Member of Parliament (MP) for Smethwick, holding the seat until his defeat in the Labour landslide at the 1945 general election, when he contested Epping, replacing the Conservative candidature of Prime Minister Winston Churchill who had transferred to the new seat of Woodford.