 They were highly ranked Italian nobility and members of the Sovereign Military Order of Malta.The only legitimate daughter of Duke Ferrante, Irene Castriota Scanderbeg, born to Andreana Acquaviva d'Aragona from the Nardò dukes, inherited the Castriota paternal estate, bringing the Duchy of Galatina and County of Soleto into the Sanseverino family after her marriage with Prince Pietrantonio Sanseverino (1508–1559).They had a son, Nicolò Bernardino Sanseverino (1541–1606).