 They have a core that branches out in regular intervals to form a small, spherical, and very dense nanocarrier.Biodegradable particles have the ability to target diseased tissue as well as deliver their payload as a controlled-release therapy.Biodegradable particles bearing ligands to P-selectin, endothelial selectin (E-selectin) and ICAM-1 have been found to adhere to inflamed endothelium.