 The package insert states that prothrombin complex concentrate is contraindicated in patients with disseminated intravascular coagulation, a pathological activation of coagulation, because giving clotting factors would only further fuel this process.However, if the PCC is given because factor levels are low, it can restore normal coagulation.As PCC products contain heparin, they are contraindicated in patients with heparin-induced thrombocytopenia.