 Instead of attempting a model-free inversion of the DSC profile to extract the underlying probability density function, they assumed a specific free energy functional with either one or two minima (similar to the Landau theory of phase transitions) thus enabling the extraction of free energy barrier heights.This model is the first of its kind in physical biochemistry that enables the determination of barrier heights from equilibrium experiments.Analysis of the DSC profile of BBL with this model resulted in zero barrier height, i.e.