 At the same time in Aleppo ִHayyim Cohen ben Abraham wrote "Meqor ִHayyim", published at Constantinople in 1649, and at Amsterdam by Menasseh ben Israel in 1650.Other Aleppo worthies are Samuel Dwek and Isaac Lopes in 1690 followed by Yehudah Kassin, Isaac Berachah and Isaac Atieh in the 18th century.From the 17th to the 19th century, several Jews of Spanish and Italian origin settled in Syria for trading reasons.