 After defending the title against Larry Marks, he took on Ricardo Mayorga and the bout ended in the 2nd round and was ruled a No contest due to a nasty cut on Lewis caused by accidental headbutt.Lewis's lost the title in a rematch to Mayorga in 2002 via 5th-round TKO.In 2003 Lewis challenged WBO Welterweight Champion Antonio Margarito, but was TKO'd in the 2nd round.