 SR 45 is the primary north–south highway of Cumberland County, where the highway meets US 60 near the county seat, Cumberland.SR 45 begins at an intersection with US 15 Business and US 460 Business near the campus of Longwood University in the town of Farmville, which has portions in Prince Edward and Cumberland counties.US 15 Business heads south on Main Street and US 460 Business heads east on Third Street; the two business routes head west together on Third Street.