 Ncs6 glycosyltransferase catalyzes the coupling between the enediyne core and the dNDP-deoxyaminosugar.The naphthoyl group is attached to the enediyne core by the enzyme NcsB2 CoA ligase.There is an additional carbonate functionality added, probably originating from CO2 (or bicarbonate), however, it remains to be determined whether this step is truly enzymatic.