 SR 49 joins US 58, a four-lane divided highway, in a concurrency to just west of Clarksville.SR 49 heads northeast along Virginia Avenue, which also carried US 58 prior to the completion of US 58's Clarksville bypass.Virginia Avenue is a four-lane divided highway from US 58 into the town of Clarksville until just after it passes under the Virginia Southern Railroad, where the highway reduces to two lanes and intersects US 15 (College Avenue).