 It cooperates with p53 to induce the activation of p53 target genes, thus activating cell-cycle checkpoints.p53 itself is an important tumor-suppressor gene sometimes known by the epithet “the guardian of the genome.” hnRNP K’s close association with p53 demonstrates its importance in DNA damage control.p53 regulates a large group of RNAs that are not translated into protein, called large intergenic noncoding RNAs (lincRNAs).