 Of the 15% of couples who are affected by infertility, 50% of those cases are due to the male partner.15-30% of male factor infertility cases can be correlated with genetic abnormalities.One of the most common identified genetic abnormalities in male factor infertility are microdeletions on the long arm of the Y chromosome (Yq), specifically at a region known as the azoospermic factor (AZF) region.