 The route runs through residential and commercial development before it widens to a four-lane divided highway and comes to a partial interchange with I-81, with access to southbound I-81 and access from northbound I-81.Past this interchange, PA 74 narrows back to a two-lane undivided road and passes through more developed areas.The road enters the borough of Carlisle and heads past businesses before it comes to an intersection with PA 641.