 In certain circumstances, men with AZF mutations can turn to assisted reproductive technologies (ART), such as intracytoplasmic sperm injection (ICSI), to help them overcome their suboptimal sperm quality.However, it is becoming increasingly more important for clinicians to screen for Yq microdeletions due to a growing body of evidence that AZF microdeletions have the capability to be vertically transmitted to male offspring.Minor et al.