 From Mercersburg, PA 75 heads north and crosses US 30 in Fort Loudon before it runs northeast through a long valley, where it has an interchange with the Pennsylvania Turnpike (Interstate 76 or I-76) in Willow Hill.The route turns north and heads into Juniata County, where it continues through another valley.PA 75 passes through Port Royal and crosses the Juniata River before it comes to its terminus at US 22/US 322.