 SR 65 begins at an intersection with US 23, US 58, and US 421 (Orby Cantrell Highway) just west of the town limit of Clinchport.The state highway heads northeast through the town as 2nd Avenue, which passes under CSX's Kingsport Subdivision.SR 65 becomes Clinch River Highway east of town and parallels the Clinch River and Norfolk Southern Railway's Clinch Valley Division northeast to Fort Blackmore, where the highway begins to run concurrently with SR 72 (Veterans Memorial Highway) to the town of Dungannon.