 PA 75 was designated in 1928 to run from US 30 in Fort Loudon north to US 22 (William Penn Highway) northeast of Port Royal.Upon designation, the route was paved between north of Richmond Furnace and PA 35 in Blairs Mills and between southwest of Port Royal and US 22 while the remainder was unpaved.By 1930, the route was paved south from Richmond Furnace to US 30 while the section between Pleasant View and southwest of Port Royal was under construction.