 A Conference to celebrate the 500th Anniversary of Tantrasangraha was organised by the Department of Theoretical Physics, University of Madras, in collaboration with the Inter-University Centre of the Indian Institute of Advanced Study, Shimla, during 11–13 March 2000, at Chennai.The Conference turned out to be an important occasion for highlighting and reviewing the recent work on the achievements in Mathematics and Astronomy of the Kerala school and the new perspectives in History of Science, which are emerging from these studies.A compilation of the important papers presented at this Conference has also been published.