 Old U.S. Route 22 is the former PA 43, and the earlier version of the newer, more traveled U.S. Highway 22.It starts in the unincorporated community of Bethel, Pennsylvania of Berks County and ends in Cetronia, just outside the city of Allentown (Lehigh County) where it becomes Main Street and then Tilghman Street.This road, although no longer a major state highway, is well traveled by those who live in the vicinity.