 SR 550 heads southeast towards Wheatland passing through an intersection with State Road 67 in Bruceville.SR 550 enters Wheatland on the northwest side of town and heads towards its eastern terminus of this section at an intersection with US 50/US 150

The eastern section of SR 550 begins in Loogootee, east of the US 50/US 150/U.S.Route 231 intersection.