 US 22 bypasses the downtown area of Lewistown as a four-lane limited access highway and becomes concurrent with US 322, continuing as a four-lane limited access highway along the Juniata and Susquehanna rivers until Harrisburg.In Harrisburg (with the US 322 concurrency ending at I-81), it continues as N Cameron Street, Arsenal Blvd., Herr St., Walnut St., Jonestown Rd., and Allentown Blvd.In Fredericksburg, US 22 becomes concurrent with I-78 for a stretch before splitting off on to the Lehigh Valley Thruway.