 Intrinsic factors generally involve differing amounts of cell-fate determinants being distributed into each daughter cell.Extrinsic factors involve interactions with neighboring cells and the micro and macro environment of the precursor cell.In addition to the aforementioned Drosophila neuronal example, it was proposed that the macrosensory organs of the Drosophila, specifically the glial cells, also arise from a similar set of asymmetric division from a single progenitor cell via regulation of the Notch signaling pathway and transcription factors.