 They challenged the relevance of Smalley's arguments to the more specific proposals advanced in "Nanosystems".Drexler maintained that both were straw man arguments, and in the case of enzymes, Prof. Klibanov wrote in 1994, "...using an enzyme in organic solvents eliminates several obstacles..." Drexler also addresses this in Nanosystems by showing mathematically that well designed catalysts can provide the effects of a solvent and can fundamentally be made even more efficient than a solvent/enzyme reaction could ever be.Drexler had difficulty in getting Smalley to respond, but in December 2003, "Chemical & Engineering News" carried a 4-part debate.