 As of 2018, the County has two constituencies (Isiolo North Constituency and Isiolo South Constituency), three sub-counties and ten wards.There are a total of 10 county assembly wards, 71 locations and 144 sub-locations

Mohamed Kuti is the second governor for Isiolo and took office in 2017 and he deputised by Ibrahim Abdi Issa.Adan Dullo Fatuma is the senator and also the first woman to be elected as a senator in Kenya.