 On 29 June 2009, Acquafresca became a member of Genoa C.F.C.as a part of the deal that saw Diego Milito and Thiago Motta move to Internazionale, and moved along with Leonardo Bonucci, Francesco Bolzoni, Riccardo Meggiorini and Ivan Fatic.He was valued at €9.5 million at that time, signing a 5-year contract.