 The landscape of Esino Lario testifies to the Alpine orogeny with the presence of fossils, boulders and caves.Human presence in the territory is documented since the Neolithic period.Esino archaeological findings from the 5th century BC show that the area was a crossing point of the main road along the eastern shore of the lake, reaching Colico and the valleys of the Adda and Imera; because of overhanging rocks between Mandello and Bellano, from Lierna the road climbed to Ortanella (currently a "frazione" of Esino) subsequently declined to Vezio and Bellano.