 The signs/symptoms of protein losing enteropathy are consistent with diarrhea, fever, and general abdominal discomfort.Swelling of the legs due to peripheral edema can also occur, however, if the PLE is related to a systemic disease such as congestive heart failure or constrictive pericarditis, then the symptoms could be of the primary disease development.The causes of protein-losing enteropathy can include GI conditions (among other causes), like the following