 Acquafresca was involved in the David Suazo transfer, which saw him move to Cagliari on a co-ownership deal for €100,000.There, he has played 36 games and scored fourteen goals.On 25 June 2008, it was confirmed that Inter had bought Cagliari's 50% of Acquafresca for €6 million, making them his sole club; however he was loaned back to Cagliari for the 2008–09 season.