 Diltiazem, a calcium-channel blocker, has been used in randomized control studies with good effect.Nitrate medications, including isosorbide dinitrate, given before meals, may also help relax the LES and improve symptoms.The inexpensive generic combination of belladonna and phenobarbital (Donnatal and other brands) may be taken three times daily as a tablet to prevent attacks or, for patients with only occasional episodes, as an elixir at the onset of symptoms.