 Together with international collaborators, his team has used supercomputers to create the first virtual organ, the virtual heart.As secretary-general of the International Union of Physiological Sciences 1993–2001, he played a major role in launching the Physiome Project, an international project to use computer simulations to create the quantitative physiological models necessary to interpret the genome, and he was elected president of the IUPS at its world congress in Kyoto in 2009.Noble is also a philosopher of biology, and his books "The Music of Life" and "Dance to the Tune of Life" challenge the foundations of current biological sciences, question the central dogma, its unidirectional view of information flow, and its imposition of a bottom-up methodology for research in the life sciences

His 2006 book "The Music of Life" examines some of the basic aspects of systems biology, and is critical of the ideas of genetic determinism and genetic reductionism.