 Simplício made his Serie A debut on 22 September 2004 in a 1–2 home loss against Bologna F.C.1909, one day shy of his 25th birthday (16 minutes played), and finished his first season with four goals in 34 games, bettering that total to ten in the following campaign.On 14 June 2006 Simplício joined fellow top division side U.S. Città di Palermo, moving alongside Parma teammate Mark Bresciano.