 Nicergoline is known to enhance the cardiac depressive effects of propranolol.At high dosages, it is advisable to seek one’s physician's guidance if combining with potent vasodilators such as bromocriptine, "Ginkgo biloba", picamilon, vinpocetine or xantinol nicotinate.Nicergoline is an ergot alkaloid derivative that acts as a potent and selective alpha-1A adrenergic receptor antagonist.