("R")-Aporphine is a dopamine receptor D1 antagonist with a "K"i of 717 nM and a dopamine receptor D2 antagonist with a "K"i of 527 nM.Aporphine and its related alkaloids bulbocapnine, boldine, glaucine, and corytuberine are antipsychotic, exert naloxone-reversible antinociceptive activity, and with the exception of corytuberine are anticonvulsant.