 The initial synthesis of 2-hydroxyquinoline from a β-ketoanilide was reported in 1886 as the Knorr quinoline synthesis.Therefore, the overall reaction is sometimes called the “Conrad-Limpach-Knorr reaction”.The synthesis of 4-hydroxyquinolines and 4-quinolones is of great importance to a variety of fields, but most notably to the medical sciences due to their use as chemotherapeutic bactericidal drugs through their ability to kill bacteria.