 Increased accessibility of these sites in receptor-bound arrestin targets the arrestin-receptor complex to the coated pit.Arrestins also bind microtubules (part of the cellular “skeleton”), where they assume yet another conformation, different from both free and receptor-bound form.Microtubule-bound arrestins recruit certain proteins to the cytoskeleton, which affects their activity and/or redirects it to microtubule-associated proteins.